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STAR Compounds Show Potential to Treat GBA1-linked Parkinson’s

Preclinical studies with two compounds, GT-02287 and GT-02329, showed they could reduce the alpha-synuclein aggregates that characterize Parkinson’s and increase glucocerebrosidase protein levels in cell models of Parkinson’s and Gaucher disease.
Henriette Lamprecht
  • 3 Year Ago - 2021-11-16 00:00:00
GT-02287 and GT-02329 are known as STARs, which stands for structurally targeted allosteric regulators. These regulators are designed to help mutated proteins fold correctly and re ...

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Namibian Sun 2024-11-25

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